Yeh Pal Ho Na Ho... Kal is a tale of treachery and trickery and the subsequent consequences where once cherished relationships in life go sour. The life of a happily married couple goes awry when the husband's friend comes into the picture. There is the happily married couple Rohan (Prakash Sagar) and Neha (Kradhika) leading a merry life. While Rohan, an architect goes to office and often works till late, his sweet wife dresses up and being an Indian wife, waits patiently, lovingly for him to come home.
Rohan's college friend Vikram (Rishabh) has a chance meeting when Rohan is on business work. The college friends renew their ties. Vikram has a girl friend Lovey (Simran), yet he is a philanderer, has a roving eye. Vikram wants to develop a relationship with Neha Vikram makes a pass to Neha but she rejects the overture and insults him. Once, this foursome goes to a discotheque where a drunk tries to get fresh with Neha. Rohan is annoyed and he beats that man. The man dies in fight. Rohan is framed for murder. Vikram tries to take his revenge by framing Rohan in a murder case and begins to blackmail his friend's wife.
Should she protect her chastity or save her husband? Eventually she has to give in to her husband's lustful friend. While Rohan is working, his wife sobs and slips into bed with her husband's best friend because he has been black mailing her about a bunch of photographs that might put her husband in jail. Rohan finds out about the relationship but what will he do?